Phenotypes associated with this allele

• Allele Symbol: Clec4a2^tm1Yiw
• Allele Name: targeted mutation 1, Yoichiro Iwakura
• Allele ID: MGI:5620799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4a2^tm1Yiw/Clec4a2^tm1Yiw	involves: 129P2/OlaHsd * C57BL/6J	MGI:5690107

Genotype
MGI:5690107

hm1

• Allelic Composition: Clec4a2^tm1Yiw/Clec4a2^tm1Yiw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:217720 )

increased dendritic cell number ( J:217720 )

• increased in mice over 12 months of age

• also in response to type II collagen injection

increased single-positive T cell number ( J:217720 )

• increased CD4+ T cell population in mice over 12 months of age

abnormal immune system physiology ( J:217720 )

increased IgG level ( J:217720 )

• increased total IgG specific for type II collagen

increased IgG1 level ( J:217720 )

• specific for type II collagen

increased IgG3 level ( J:217720 )

• specific for type II collagen

abnormal circulating interleukin level ( J:217720 )

increased circulating interleukin-10 level ( J:217720 )

• in response to type II collagen

increased circulating interleukin-17 level ( J:217720 )

• in response to type II collagen

increased circulating interleukin-23 level ( J:217720 )

• in response to type II collagen

increased circulating interleukin-4 level ( J:217720 )

• in response to type II collagen

increased autoantibody level ( J:217720 )

• higher levels of autoantibodies in aged mice

• IgM and IgG to rheumatoid factor present

• IgG to collagen type II present

• antibodies to Sjogren syndrom antigens A and B present

increased anti-nuclear antigen antibody level ( J:217720 )

increased inflammatory response ( J:217720 )

salivary gland inflammation ( J:217720 )

• sialadenitis develops spontaneously in 70% of mice by 6-12 months of age

• accumulation of lymphocytes in interstitium

• destruction of the small duct associated with mononuclear cell infiltration

enthesitis ( J:217720 )

• 39% develop enthesitis by 12 months

joint inflammation ( J:217720 )

• joint abnormalities in 11% of homozygotes at 4 months including swelling and redness

• increases to 28% by 6 months leading to joint deformity and ankylosis

• most notably in ankle joints of hind limbs

• synovitis develops in 17% of mice

increased susceptibility to induced arthritis ( J:217720 )

• incidence and severity of collagen induced arthritis is increased

• significantly increased proliferative response to type II collagen

skeleton

enthesitis ( J:217720 )

• 39% develop enthesitis by 12 months

joint inflammation ( J:217720 )

• joint abnormalities in 11% of homozygotes at 4 months including swelling and redness

• increases to 28% by 6 months leading to joint deformity and ankylosis

• most notably in ankle joints of hind limbs

• synovitis develops in 17% of mice

increased susceptibility to induced arthritis ( J:217720 )

• incidence and severity of collagen induced arthritis is increased

• significantly increased proliferative response to type II collagen

abnormal fibrocartilage morphology ( J:217720 )

♂ • fibrocartilage proliferation in some aged male mice

increased bone ossification ( J:217720 )

♂ • increased bone formation in some aged mice

hematopoietic system

increased dendritic cell number ( J:217720 )

• increased in mice over 12 months of age

• also in response to type II collagen injection

increased single-positive T cell number ( J:217720 )

• increased CD4+ T cell population in mice over 12 months of age

increased IgG level ( J:217720 )

• increased total IgG specific for type II collagen

increased IgG1 level ( J:217720 )

• specific for type II collagen

increased IgG3 level ( J:217720 )

• specific for type II collagen

endocrine/exocrine glands

salivary gland inflammation ( J:217720 )

• sialadenitis develops spontaneously in 70% of mice by 6-12 months of age

• accumulation of lymphocytes in interstitium

• destruction of the small duct associated with mononuclear cell infiltration

digestive/alimentary system

salivary gland inflammation ( J:217720 )

• sialadenitis develops spontaneously in 70% of mice by 6-12 months of age

• accumulation of lymphocytes in interstitium

• destruction of the small duct associated with mononuclear cell infiltration

homeostasis/metabolism

abnormal circulating interleukin level ( J:217720 )

increased circulating interleukin-10 level ( J:217720 )

• in response to type II collagen

increased circulating interleukin-17 level ( J:217720 )

• in response to type II collagen

increased circulating interleukin-23 level ( J:217720 )

• in response to type II collagen

increased circulating interleukin-4 level ( J:217720 )

• in response to type II collagen