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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gp6tm1Beni
targeted mutation 1, Bernhard Nieswandt
MGI:5620877
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gp6tm1Beni/Gp6tm1Beni involves: 129 * C57BL/6 MGI:5694693
cn2
 		Gp6tm1Beni/Gp6tm1Beni
Clec1btm1.1Arte/Clec1btm1.1Arte
Tg(Pf4-icre)Q3Rsko/0 		involves: 129 * C57BL/6 MGI:5694695


Genotype
MGI:5694693
hm1
Allelic
Composition		 Gp6tm1Beni/Gp6tm1Beni
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp6tm1Beni mutation (0 available); any Gp6 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal blood coagulation ( J:217963 )
• CLEC-2 receptor depletion using INU1 antibody
• platelets unresponsive to collagen related peptide, convulxin, and rhodocytin
increased bleeding time ( J:217963 )
• severely prolonged bleeding times




Genotype
MGI:5694695
cn2
Allelic
Composition		 Gp6tm1Beni/Gp6tm1Beni
Clec1btm1.1Arte/Clec1btm1.1Arte
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec1btm1.1Arte mutation (0 available); any Clec1b mutation (17 available)
Gp6tm1Beni mutation (0 available); any Gp6 mutation (19 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased bleeding time ( J:217963 )
• markedly prolonged tail-bleeding times

hematopoietic system
abnormal platelet cell number ( J:217963 )
• moderately reduced platelet count

reproductive system
decreased litter size ( J:217963 )
• litters of 2-6 mice
• fewer than 35% double homozygotes

immune system
abnormal lymphatic vessel morphology ( J:217963 )
• blood filled lymphatics in the intestine
• more pronounced than in Clec1btm1.1Arte single homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory