mortality/aging
• no homozygotes are found at E10.5-E13.5, while embryos are detected at E6.5-E.9.5, indicating lethality between E9.5 and E10.5
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Allele Symbol Allele Name Allele ID |
ApcM1Tno Mutation 1, Tetsuo Noda MGI:5620880 |
Summary |
3 genotypes |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no homozygotes are found at E10.5-E13.5, while embryos are detected at E6.5-E.9.5, indicating lethality between E9.5 and E10.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
|
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
|
• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors
• trichogenic tumors in males arise from 9 months of age
|
• trichogenic tumors are trichoepithelioma and pilomatricoma
|
• trichogenic tumors are trichoepithelioma and pilomatricoma
|
• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas
|
• 54.2% of females and 93.3% of males exhibit osteomas
• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas
• osteomas in males arise from 9 months of age
|
• females become moribund as early as 9 weeks of age
|
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
|
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
|
• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors
• trichogenic tumors in males arise from 9 months of age
|
• trichogenic tumors are trichoepithelioma and pilomatricoma
|
• trichogenic tumors are trichoepithelioma and pilomatricoma
|
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
|
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
|
• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas
|
• 54.2% of females and 93.3% of males exhibit osteomas
• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas
• osteomas in males arise from 9 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
familial adenomatous polyposis | DOID:0050424 |
OMIM:PS175100 |
J:218227 |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• females exhibit multiple breast cancers
|
• some mutants of both genders exhibit multiple trichogenic tumors
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• males exhibit multiple osteomas
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• 76% of males survive up to 60 weeks of age
• only 50% of females survive up to 50 weeks of age
|
|
• females exhibit multiple breast cancers
|
• some mutants of both genders exhibit multiple trichogenic tumors
|
|
• females exhibit multiple breast cancers
|
|
• males exhibit multiple osteomas
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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