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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		ApcM1Tno
Mutation 1, Tetsuo Noda
MGI:5620880
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		ApcM1Tno/ApcM1Tno involves: C57BL/6 * DBA/2JJcl MGI:5688289
ht2
 		ApcM1Tno/Apc+ either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl) MGI:5688288
ht3
 		ApcM1Tno/Apc+ involves: C57BL/6 * DBA/2JJcl MGI:5688286


Genotype
MGI:5688289
hm1
Allelic
Composition		 ApcM1Tno/ApcM1Tno
Genetic
Background		 involves: C57BL/6 * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcM1Tno mutation (0 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:218227 )
• no homozygotes are found at E10.5-E13.5, while embryos are detected at E6.5-E.9.5, indicating lethality between E9.5 and E10.5




Genotype
MGI:5688288
ht2
Allelic
Composition		 ApcM1Tno/Apc+
Genetic
Background		 either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcM1Tno mutation (0 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:218227 )
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
increased mammary adenocarcinoma incidence ( J:218227 )
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
increased skin tumor incidence ( J:218227 )
• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors
• trichogenic tumors in males arise from 9 months of age
increased pilomatricoma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma
increased trichoepithelioma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma
increased osteosarcoma incidence ( J:218227 )
• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas
increased osteoma incidence ( J:218227 )
• 54.2% of females and 93.3% of males exhibit osteomas
• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas
• osteomas in males arise from 9 months of age

mortality/aging
premature death ( J:218227 )
• females become moribund as early as 9 weeks of age

integument
increased mammary gland tumor incidence ( J:218227 )
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
increased mammary adenocarcinoma incidence ( J:218227 )
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
increased skin tumor incidence ( J:218227 )
• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors
• trichogenic tumors in males arise from 9 months of age
increased pilomatricoma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma
increased trichoepithelioma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:218227 )
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
increased mammary adenocarcinoma incidence ( J:218227 )
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

skeleton
increased osteosarcoma incidence ( J:218227 )
• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas
increased osteoma incidence ( J:218227 )
• 54.2% of females and 93.3% of males exhibit osteomas
• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas
• osteomas in males arise from 9 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
familial adenomatous polyposis DOID:0050424 OMIM:PS175100
 J:218227




Genotype
MGI:5688286
ht3
Allelic
Composition		 ApcM1Tno/Apc+
Genetic
Background		 involves: C57BL/6 * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcM1Tno mutation (0 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:218227 )
• females exhibit multiple breast cancers
increased skin tumor incidence ( J:218227 )
• some mutants of both genders exhibit multiple trichogenic tumors
increased osteoma incidence ( J:218227 )
• males exhibit multiple osteomas

mortality/aging
premature death ( J:218227 )
• 76% of males survive up to 60 weeks of age
• only 50% of females survive up to 50 weeks of age

integument
increased mammary gland tumor incidence ( J:218227 )
• females exhibit multiple breast cancers
increased skin tumor incidence ( J:218227 )
• some mutants of both genders exhibit multiple trichogenic tumors

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:218227 )
• females exhibit multiple breast cancers

skeleton
increased osteoma incidence ( J:218227 )
• males exhibit multiple osteomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory