Phenotypes associated with this allele

• Allele Symbol: Nox4^tm1Syb
• Allele Name: targeted mutation 1, Yun Soo Bae
• Allele ID: MGI:5620884
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nox4^tm1Syb/Nox4^tm1Syb	involves: 129S4/SvJae	MGI:6490302
hm2	Nox4^tm1Syb/Nox4^tm1Syb	involves: 129S4/SvJae * C57BL/6N	MGI:5695663

Genotype
MGI:6490302

hm1

• Allelic Composition: Nox4^tm1Syb/Nox4^tm1Syb
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased kidney apoptosis ( J:298830 )

• reduced apoptosis after LPS injection

decreased renal tubule apoptosis ( J:298830 )

• reduced apoptosis upon LPS stimulation of renal tubular epithelial cells (RTECs)

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:298830 )

• no increase in intra- or extracellular hydrogen peroxide generation upon LPS stimulation of renal tubular epithelial cells (RTECs)

• suppressed extracellular hydrogen peroxide generation by kidneys after LPS injection

• attenuated TNFA and IL1b induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

• no TNFA and IL1b production by kidneys after LPS injection

immune system

decreased interleukin-1 beta secretion ( J:298830 )

• attenuated IL1b induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

decreased tumor necrosis factor secretion ( J:298830 )

• attenuated TNFA induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

decreased susceptibility to endotoxin shock ( J:298830 )

• significantly increased survival rate after LPS injection

• no increase in intra- or extracellular hydrogen peroxide generation upon LPS stimulation of renal tubular epithelial cells (RTECs)

• suppressed extracellular hydrogen peroxide generation by kidneys after LPS injection

• attenuated TNFA and IL1b induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

• no TNFA and IL1b production by kidneys after LPS injection

• no acute kidney injury (AKI) after LPS injection

• suppressed macrophage and neutrophil infiltration of kidney after LPS induction

• reduced kidney apoptosis after LPS injection

• no glomerular swelling after LPS injection

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:298830 )

• significantly increased survival rate after LPS injection

• no acute kidney injury (AKI) after LPS injection

• suppressed macrophage and neutrophil infiltration of kidney after LPS induction

• reduced kidney apoptosis after LPS injection

• no glomerular swelling after LPS injection

renal/urinary system

decreased kidney apoptosis ( J:298830 )

• reduced apoptosis after LPS injection

decreased renal tubule apoptosis ( J:298830 )

• reduced apoptosis upon LPS stimulation of renal tubular epithelial cells (RTECs)

Genotype
MGI:5695663

hm2

• Allelic Composition: Nox4^tm1Syb/Nox4^tm1Syb
• Genetic Background: involves: 129S4/SvJae * C57BL/6N

cellular

abnormal redox activity ( J:218649 )

♂ • stimulation of mouse aortic smooth muscle cells with Pam3CSK4 results in increased generation of reactive oxygen species (ROS)