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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Npr3skm1
skeletal morphology mutant 1
MGI:5620887
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Npr3skm1/Npr3skm1 involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J MGI:5660811


Genotype
MGI:5660811
hm1
Allelic
Composition
Npr3skm1/Npr3skm1
Genetic
Background
involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr3skm1 mutation (0 available); any Npr3 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• some mice exhibit an elongated body (torso)
• at weaning, mice are visibly leaner than littermate controls
• mice are thin at 6 weeks of age

skeleton
• at 6 weeks of age, hemivertebrae are seen in the tail region
• at 6 weeks of age, fused vertebrae are seen in the tail region
• some mice exhibit kyphosis and a kinked tail
• marked thoracolumbar kyphosis at 6 weeks of age
• mice display a skeletal overgrowth phenotype, resulting in an elongated body and thoracic kyphosis

limbs/digits/tail
• at 6 weeks of age, mice display arachnodactyly characterized by elongated phalanges
• at 6 weeks of age, hemivertebrae are seen in the tail region
• at 6 weeks of age, fused vertebrae are seen in the tail region
• mice with kyphotic spines display kinked tails
• kinked tail is due to either the presence of hemivertebrae or fused vertebrae in the tail region





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory