growth/size/body
• some mice exhibit an elongated body (torso)
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• at weaning, mice are visibly leaner than littermate controls
• mice are thin at 6 weeks of age
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skeleton
• at 6 weeks of age, hemivertebrae are seen in the tail region
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• at 6 weeks of age, fused vertebrae are seen in the tail region
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• some mice exhibit kyphosis and a kinked tail
• marked thoracolumbar kyphosis at 6 weeks of age
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• mice display a skeletal overgrowth phenotype, resulting in an elongated body and thoracic kyphosis
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limbs/digits/tail
• at 6 weeks of age, mice display arachnodactyly characterized by elongated phalanges
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• at 6 weeks of age, hemivertebrae are seen in the tail region
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• at 6 weeks of age, fused vertebrae are seen in the tail region
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kinked tail
(
J:218364
)
• mice with kyphotic spines display kinked tails
• kinked tail is due to either the presence of hemivertebrae or fused vertebrae in the tail region
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