Phenotypes associated with this allele

• Allele Symbol: Esrrg^tm1Sjda
• Allele Name: targeted mutation 1, Sally J Dawson
• Allele ID: MGI:5620890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esrrg^tm1Sjda/Esrrg^tm1Sjda	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5660899

Genotype
MGI:5660899

hm1

• Allelic Composition: Esrrg^tm1Sjda/Esrrg^tm1Sjda
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:211740 )

• only a small fraction of homozygotes survive into adulthood (18 weeks of age)

postnatal lethality, incomplete penetrance ( J:211740 )

• most homozygotes die in the early postnatal period, prior to the onset of hearing

hearing/vestibular/ear

abnormal auditory brainstem response waveform shape ( J:211740 )

• recorded potentials are of lower amplitude and altered in waveform

increased or absent threshold for auditory brainstem response ( J:211740 )

• homozygotes display significantly elevated hearing thresholds at 5 weeks and 12 weeks of age

• at 12 weeks of age, average hearing thresholds in females are 15 dB worse than in males

impaired hearing ( J:211740 )

• at 5 weeks of age, homozygotes exhibit a mild 25-dB hearing loss relative to wild-type or heterozygous controls

• at 12 weeks of age, females exhibit greater hearing loss than age-matched males