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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk4tm1Melo
targeted mutation 1, Sylvain Meloche
MGI:5620956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk4tm1Melo/Mapk4tm1Melo B6.129-Mapk4tm1Melo MGI:5621011
cx2
 		Mapk4tm1Melo/Mapk4tm1Melo
Mapk6tm1Melo/Mapk6tm1Melo 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5621012


Genotype
MGI:5621011
hm1
Allelic
Composition		 Mapk4tm1Melo/Mapk4tm1Melo
Genetic
Background		 B6.129-Mapk4tm1Melo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk4tm1Melo mutation (1 available); any Mapk4 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:219480 )
• mice are viable and fertile and exhibit no gross morphological or physiological anomalies




Genotype
MGI:5621012
cx2
Allelic
Composition		 Mapk4tm1Melo/Mapk4tm1Melo
Mapk6tm1Melo/Mapk6tm1Melo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk4tm1Melo mutation (1 available); any Mapk4 mutation (65 available)
Mapk6tm1Melo mutation (1 available); any Mapk6 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:219480 )
• as in Mapk6tm1Melo homozygotes

growth/size/body
decreased body size ( J:219480 )
• as in Mapk6tm1Melo homozygotes
decreased body weight ( J:219480 )
• as in Mapk6tm1Melo homozygotes

respiratory system
abnormal lung saccule morphology ( J:219480 )
• decreased saccular space as in Mapk6tm1Melo homozygotes
increased type II pneumocyte number ( J:219480 )
• as in Mapk6tm1Melo homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory