Phenotypes associated with this allele

• Allele Symbol: Ndfip1^tm1.1Sest
• Allele Name: targeted mutation 1.1, Seong-Seng Tan
• Allele ID: MGI:5620967
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndfip1^tm1.1Sest/Ndfip1^tm1.1Sest	involves: C57BL/6	MGI:5697319

Genotype
MGI:5697319

hm1

• Allelic Composition: Ndfip1^tm1.1Sest/Ndfip1^tm1.1Sest
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:212711 )

• in response to iron-induced toxicity, cultured mesencephalic dopaminergic neurons isolated from E13 mutant embryos show a significant increase in neuronal cell death relative to wild-type controls, as shown by TUNEL analysis

abnormal iron homeostasis ( J:212711 )

• in culture, mesencephalic dopaminergic neurons isolated from E13 mutant embryos display increased levels of the divalent metal transporter SLC11A2 (DMT1) relative to wild-type controls, suggesting misregulation of iron homeostasis

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:212711 )

• in response to iron-induced toxicity, cultured mesencephalic dopaminergic neurons isolated from E13 mutant embryos show a significant increase in neuronal cell death relative to wild-type controls, as shown by TUNEL analysis

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:212711 )

• in response to iron-induced toxicity, cultured mesencephalic dopaminergic neurons isolated from E13 mutant embryos show a significant increase in neuronal cell death relative to wild-type controls, as shown by TUNEL analysis