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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfaip3tm1Homy
targeted mutation 1, Hiroaki Honda
MGI:5621002
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Tnfaip3tm1Homy/Tnfaip3tm1Homy
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:5698269
cn2
Tnfaip3tm1Homy/Tnfaip3tm1Homy
Tg(Mx1-cre)1Cgn/?
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5698264


Genotype
MGI:5698269
cn1
Allelic
Composition
Gt(ROSA)26Sortm9(cre/ESR1)Arte/?
Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tnfaip3tm1Homy mutation (1 available); any Tnfaip3 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Microemboli and necrotic areas in Tnfaip3tm1Homy/Tnfaip3tm1Homy Gt(ROSA)26Sortm9(cre/ESR1)Arte/? liver

hematopoietic system
N
• no spontaneous development of abnormal phenotype
• marked drop in hematopoietic cell after tamoxifen administration

mortality/aging
• die within several days of tamoxifen administration

liver/biliary system
• microembolic and necrotic areas in the liver after tamoxifen administration (J:212681)
• with white spots after tamoxifen administration (J:212681)

cellular
• massive apoptosis in major organs after tamoxifen administration

immune system
• elevated levels of GM-CSF after tamoxifen administration
• particularly elevated after tamoxifen administration
• elevated after tamoxifen administration
• particularly elevated after tamoxifen administration
• particularly elevated TNF-alpha levels after tamoxifen administration

homeostasis/metabolism
• elevated levels of GM-CSF after tamoxifen administration
• particularly elevated after tamoxifen administration
• elevated after tamoxifen administration
• particularly elevated after tamoxifen administration
• particularly elevated TNF-alpha levels after tamoxifen administration
• die within several days of tamoxifen administration

endocrine/exocrine glands




Genotype
MGI:5698264
cn2
Allelic
Composition
Tnfaip3tm1Homy/Tnfaip3tm1Homy
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation (7 available)
Tnfaip3tm1Homy mutation (1 available); any Tnfaip3 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Inflammation in the lung and liver and destruction of spleen architecture of Tnfaip3tm1Homy/Tnfaip3tm1Homy Tg(Mx1-cre)1Cgn/? mice

growth/size/body
• spontaneous emaciation and cachexia without stimulation with polyinosinic:polycytidylic acid (pIpC)

mortality/aging
• most mice die within six months of birth

hematopoietic system
N
• no significant differences in WBC and platelets between homozygotes and controls at 3 and 6 months
• proliferation of myeloid cells
• progressive anemia
• reduced B lymphoid cell numbers in peripheral blood
• destruction of spleen architecture due to proliferation of white blood cells of myeloid origin

immune system
• proliferation of myeloid cells
• reduced B lymphoid cell numbers in peripheral blood
• destruction of spleen architecture due to proliferation of white blood cells of myeloid origin
• significantly increased levels of GM-CSF
• significantly increased TNF-alpha levels
• swelling of lymph nodes
• infiltration with hematopoietic cells
• infiltration of lungs with hematopoietic cells

liver/biliary system
• infiltration with hematopoietic cells

respiratory system
• infiltration of lungs with hematopoietic cells

homeostasis/metabolism
• significantly increased levels of GM-CSF
• significantly increased TNF-alpha levels





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory