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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ntrk1tm1.1Azmo
targeted mutation 1.1, Aziz Moqrich
MGI:5621022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo involves: 129S2/SvPas MGI:5699563


Genotype
MGI:5699563
hm1
Allelic
Composition
Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk1tm1.1Azmo mutation (0 available); any Ntrk1 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Peripheral, but not central innervation is drastically reduced in Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo mice

nervous system
N
• dorsal root ganglia appear normal
• spinal cord sensory innervation is normal
• sensory nerve targeting to skin is defective, disorganized and drastically reduced
• neurite outgrowth from dorsal root ganglion explants are of lower density and tortuous in appearance
• sensory neuron in adult dorsal root ganglia are very modestly reduced in number
• drastic decrease in peptidergic nociceptive fibers in glabrous skin of adults

integument
• sensory nerve targeting to skin is defective, disorganized and drastically reduced

behavior/neurological
N
• locomotor and anxiety behavior is normal
• decreased response to a hot plate at 52C
• greater tolerance for cold (14C)
• reduced response in formalin test for continuous pain
• reduced hyperalgesic response to complete Freund's adjuvant





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory