nervous system
N |
• dorsal root ganglia appear normal
• spinal cord sensory innervation is normal
|
• sensory nerve targeting to skin is defective, disorganized and drastically reduced
|
• neurite outgrowth from dorsal root ganglion explants are of lower density and tortuous in appearance
|
• sensory neuron in adult dorsal root ganglia are very modestly reduced in number
• drastic decrease in peptidergic nociceptive fibers in glabrous skin of adults
|
integument
• sensory nerve targeting to skin is defective, disorganized and drastically reduced
|
behavior/neurological
N |
• locomotor and anxiety behavior is normal
|
• decreased response to a hot plate at 52C
• greater tolerance for cold (14C)
|
• reduced response in formalin test for continuous pain
|
• reduced hyperalgesic response to complete Freund's adjuvant
|