All Phenotypes Crx<tm2.1Smgc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crx^tm2.1Smgc
targeted mutation 2.1, Shiming Chen
MGI:5621025

Summary

2 genotypes

Allelic Composition	Crx^tm2.1Smgc/Crx^tm2.1Smgc
Genetic Background	B6.129X1(CBA)-Crx^tm2.1Smgc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crx^tm2.1Smgc mutation (0 available); any Crx mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Crx^tm1.1Smgc/Crx^tm1.1Smgc, Crx^tm2.1Smgc/Crx^tm2.1Smgc, and Crx^tm1Clc/Crx^tm1Clc mice develop Leber Congenital Amaurosis-like retinopathy

vision/eye

vision/eye phenotype ( J:211011 )

N	• normal lamellar formation of the retina at 14 days of age

abnormal retina layer morphology ( J:211011 )

• no outer segment formation at 14 days through 3 months

• loss of outer layer nuclei starting around 1 month

• only 7-9 rows at 1 month compared to about 12 rows in controls

• 2-3 rows at 3 months

• apoptosis at 21 and 35 days of age

• no light or dark adapted responses

nervous system

• no outer segment formation at 14 days through 3 months

Allelic Composition	Crx^tm2.1Smgc/Crx⁺
Genetic Background	B6.129X1(CBA)-Crx^tm2.1Smgc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crx^tm2.1Smgc mutation (0 available); any Crx mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Crx^tm1.1Smgc/Crx⁺ but not Crx^tm2.1Smgc/Crx⁺ develop dominant retinopathy

vision/eye

vision/eye phenotype ( J:211011 )

N	• normal retinal morphology at all ages • cones are located normally by 1 month of age • opsin expression and distribution normal

• normal overall cone density through 1 year of age despite a modestly reduced density in the central region of the retina

decreased b-wave amplitude ( J:211011 )

• EGR deficits do not appear until 6 months of age

• minor light adapted B wave deficiencies

nervous system

• normal overall cone density through 1 year of age despite a modestly reduced density in the central region of the retina

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24