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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*)D-14Dbo
transgene insertion D-14, David R Borchelt
MGI:5621172
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(SOD1)2Gur/0
Tg(SOD1*)D-14Dbo/0
involves: C3H/HeJ * C57BL/6 * C57BL/6J * SJL MGI:5621175
tg2
Tg(SOD1*)D-14Dbo/0 involves: C3H/HeJ * C57BL/6J MGI:5621173


Genotype
MGI:5621175
cx1
Allelic
Composition
Tg(SOD1)2Gur/0
Tg(SOD1*)D-14Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1)2Gur mutation (2 available)
Tg(SOD1*)D-14Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice develop hindlimb paralysis between 12 and 20 months of age

nervous system
• within surviving motor neurons, wispy fibrillar ubiquitin, mutant SOD1, and Thioflavin S positive inclusions are seen that do not contain wild-type SOD1

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:218091




Genotype
MGI:5621173
tg2
Allelic
Composition
Tg(SOD1*)D-14Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*)D-14Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit incomplete penetrance of paralysis between 500 and 730 days of age

nervous system
• the spinal cords show mutant protein immunoreactive fibrillar inclusions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:218091





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory