mortality/aging
• mice develop a diseased phenotype beginning 4-6 weeks following tamoxifen treatment, with multiple organ failure leading to lethality
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respiratory system
• mice develop respiratory distress 4-6 weeks after tamoxifen treatment
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behavior/neurological
• mice exhibit loss of mobility 4-6 weeks after tamoxifen treatment
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cellular
• tamoxifen-treated mice exhibit mitochondrial aggregation in renal cortex and liver parenchyma and small mitochondria aggregation in Schwann cell cytoplasm of the sciatic nerve, most likely indicating un-fused mitochondria
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homeostasis/metabolism
• mice develop bloating due to ascites accumulation 4-6 weeks after tamoxifen treatment
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integument
• mice exhibit skin follicle erection 4-6 weeks after tamoxifen treatment
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nervous system
• tamoxifen-treated mice show abnormal myelination of the tibial nerve, with abnormal myelin configurations surrounding some axons
• tibial nerves of tamoxifen-treated mice show double myelinated axons in which the inner portion of the outer sheath is decompacting
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