Phenotypes associated with this allele

• Allele Symbol: Rab11a^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5629313
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab11a^tm1b(KOMP)Wtsi/Rab11a^tm1b(KOMP)Wtsi	B6N(Cg)-Rab11a^tm1b(KOMP)Wtsi/J	MGI:5767778
ht2	Rab11a^tm1b(KOMP)Wtsi/Rab11a^+	B6N(Cg)-Rab11a^tm1b(KOMP)Wtsi/J	MGI:5888407

Genotype
MGI:5767778

hm1

• Allelic Composition: Rab11a^{tm1b(KOMP)Wtsi}/Rab11a^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Rab11a^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0267_4_C09

Data Sources

IMPC Data for Rab11a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rab11a^{tm1b(KOMP)Wtsi}/Rab11a^{tm1b(KOMP)Wtsi} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg-cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

Genotype
MGI:5888407

ht2

• Allelic Composition: Rab11a^{tm1b(KOMP)Wtsi}/Rab11a⁺
• Genetic Background: B6N(Cg)-Rab11a^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0267_4_C09

Data Sources

IMPC Data for Rab11a

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

♀

IMPC - JAX

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - JAX