Phenotypes associated with this allele

• Allele Symbol: Kcnq2^tm2.1Snhr
• Allele Name: targeted mutation 2.1, Shinichi Hirose
• Allele ID: MGI:5629428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnq2^tm2.1Snhr/Kcnq2^tm2.1Snhr	B6.Cg-Kcnq2^tm2.1Snhr	MGI:5703896
ht2	Kcnq2^tm2.1Snhr/Kcnq2^+	B6.Cg-Kcnq2^tm2.1Snhr	MGI:5703897

Genotype
MGI:5703896

hm1

• Allelic Composition: Kcnq2^tm2.1Snhr/Kcnq2^tm2.1Snhr
• Genetic Background: B6.Cg-Kcnq2^tm2.1Snhr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:213443 )

N • no abnormalities in open field, rotarod, and hot plate tests

clonic seizures ( J:213443 )

• some mice display spontaneous seizures 6 weeks after birth

• generalized forelimb and hind limb clonic seizure followed by arrest, salivation and weak myoclonic seizure

nervous system

clonic seizures ( J:213443 )

• some mice display spontaneous seizures 6 weeks after birth

• generalized forelimb and hind limb clonic seizure followed by arrest, salivation and weak myoclonic seizure

abnormal nervous system electrophysiology ( J:213443 )

• at 4 and 10 weeks a significant M current reduction is seen at higher depolarizing potentials

Genotype
MGI:5703897

ht2

• Allelic Composition: Kcnq2^tm2.1Snhr/Kcnq2⁺
• Genetic Background: B6.Cg-Kcnq2^tm2.1Snhr

behavior/neurological

clonic seizures ( J:213443 )

• high cFos expression in the dorsal hippocampus suggestive of early un-noticed seizure activity

• increased seizure severity compared to controls after PTZ injection

nervous system

clonic seizures ( J:213443 )

• high cFos expression in the dorsal hippocampus suggestive of early un-noticed seizure activity

• increased seizure severity compared to controls after PTZ injection

abnormal nervous system electrophysiology ( J:213443 )

• at 10 weeks a significant M current reduction is seen at higher depolarizing potentials