Phenotypes associated with this allele

• Allele Symbol: Stk31^tm2Jw
• Allele Name: targeted mutation 2, Jeremy Wang
• Allele ID: MGI:5629553
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk31^tm2Jw/Stk31^tm2Jw	B6J.Cg-Stk31^tm2Jw	MGI:5660383
hm2	Stk31^tm2Jw/Stk31^tm2Jw	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:5660381

Genotype
MGI:5660383

hm1

• Allelic Composition: Stk31^tm2Jw/Stk31^tm2Jw
• Genetic Background: B6J.Cg-Stk31^tm2Jw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:213823 )

♂N • after backcrossing to the C57BL/6J strain for ten generations, males are still fertile with normal testis weight and normal sperm count at 8 weeks of age

Genotype
MGI:5660381

hm2

• Allelic Composition: Stk31^tm2Jw/Stk31^tm2Jw
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

reproductive system

reproductive system phenotype ( J:213823 )

N • both male and female mice appear to be grossly healthy and fertile

N • males exhibit normal testis size and testis histology at 8 weeks of age

N • following exposure of young female pups to gamma-irradiation, both wild-type and mutant ovaries lack primordial follicles, suggesting that the DNA damage checkpoint in oocytes is intact