All Phenotypes Bscl2<tm1.1Gliu> MGI Mouse

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
male infertility	DOID:12336		J:211072

abnormal male germ cell morphology ( J:211072 )

• oligoasthenoteratozoospermia

asthenozoospermia ( J:211072 )

• lower percentage of motile sperm

abnormal testis morphology ( J:211072 )

• testes contain many degenerating masses composed of fragmented spermatids and large lipid droplets

abnormal spermatogenesis ( J:211072 )

• testes contains prominent bundles of two or more interconnected sperm

oligozoospermia ( J:211072 )

• lower sperm counts

• cauda epididymides are almost entirely devoid of sperm but contain numerous spherical cells

teratozoospermia ( J:211072 )

• sperm is morphologically abnormal, with 18% of sperm showing head and tail abnormalities compared to 6% of controls

abnormal sperm flagellum morphology ( J:211072 )

• tail defects include folded sperm or sheath abnormalities

abnormal sperm head morphology ( J:211072 )

• defects in sperm heads include lack of the usual hook and banana-like or amorphous forms

• some sperm exhibit cavities in the sperm head

abnormal spermatid morphology ( J:211072 )

• the numbers of spermatocytes in stages VII and VII seminiferous tubules are similar to wild-type mice, but tubules contain fewer round spermatids, indicating loss of round spermatids

• presence of large ectopic lipid droplets in round, elongating and elongated spermatids

• spermatids exhibit defects in chromatin condensation

abnormal spermiogenesis ( J:211072 )

• males exhibit structural defects in late spermiogenesis; abnormal clustering of late spermatids of seminiferous tubules at stages VII and VIII of the seminiferous epithelial cycle , with the heads of these spermatids randomly oriented instead of being aligned perpendicular to the seminiferous tubule basement membrane

• seminiferous tubule sections near completion of spermiogenesis contain massive accumulations of spermatids in bundle-like structures

male infertility ( J:211072 )

• males exhibit normal mating behavior, however, no pregnancies or offspring are seen in breeding pairs of wild-type females and mutant males

• however, males show normal serum FSH, LH, testosterone and estradiol levels