All Phenotypes Tnfrsf11a<tm1.1Irw> MGI Mouse

decreased plasma cell number ( J:226603 )

• reduced numbers of IgA+ antibody secreting cells in intestinal lamina propria 1 week after weaning as compared to controls

• number of IgA+ cells increases by 3 weeks, but remains less than controls

decreased IgA level ( J:226603 )

• fecal IgA production is reduced as compared to controls

• serum IgA levels are lower through the first 1 to 3 weeks after weaning, but increase to same levels of control 3 weeks after weaning

• following exposure to foreign antigen (horse ferritin), anti-ferritin IgA levels are similar to unimmunized controls

abnormal Peyer's patch morphology ( J:226603 )

• uptake of bacteria into Peyer's patches is less than 1% of control uptake; most section exhibit no bacterial uptake

• uptake of particulates (polystyrene beads) into Peyer's patches is reduced by over 90%

abnormal Peyer's patch epithelium morphology ( J:219915 , J:226603 )

• absent M cells from follicle-associated epithelium overlying the Peyer's patch resulting in impeded uptake of amorphous Mg-substituted calcium phosphate (AMCP) nanomineral from the gut (J:219915)

• M cells are not deteced in Peyer's patch domes (J:226603)

abnormal Peyer's patch follicle morphology ( J:226603 )

• reduction in size of Peyers patch B cell follicles 1 week after weaning as compared to control

• follicle size increases by 3 weeks, but remains smaller than controls

abnormal Peyer's patch T cell area morphology ( J:226603 )

• Peyers patches contain fewer follicular helper T cells than controls 2 weeks after weaning, however, by 6 weeks numbers are comparable

abnormal Peyer's patch germinal center morphology ( J:226603 )

• Peyers patches contain fewer germinal center B cells than controls 2 weeks after weaning, however, by 6 weeks numbers are comparable.

• germinal cell development is delayed