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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr9M9Btlr
mutation 9, Bruce Beutler
MGI:5632141
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr9M9Btlr/Tlr9M9Btlr C57BL/6J-Tlr9M9Btlr MGI:5632142
ht2
 		Tlr9M9Btlr/Tlr9+ C57BL/6J-Tlr9M9Btlr MGI:5632143


Genotype
MGI:5632142
hm1
Allelic
Composition		 Tlr9M9Btlr/Tlr9M9Btlr
Genetic
Background		 C57BL/6J-Tlr9M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M9Btlr mutation (0 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:220063 )
• mice with this mutation exhibit decreased TNFalpha secretion in response to the TLR9 ligand CpG oligodeoxynucleotide; secretion is lower in homozygous than in heterozygous mutant mice.




Genotype
MGI:5632143
ht2
Allelic
Composition		 Tlr9M9Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M9Btlr mutation (0 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:220063 )
• mice with this mutation exhibit decreased TNFalpha secretion in response to the TLR9 ligand CpG oligodeoxynucleotide; secretion in heterozygous mutant mice is intermediate between that of wild-type and homozygous mutants.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory