About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr9M9Btlr
mutation 9, Bruce Beutler
MGI:5632141
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr9M9Btlr/Tlr9M9Btlr C57BL/6J-Tlr9M9Btlr MGI:5632142
ht2
 		Tlr9M9Btlr/Tlr9+ C57BL/6J-Tlr9M9Btlr MGI:5632143


Genotype
MGI:5632142
hm1
Allelic
Composition		 Tlr9M9Btlr/Tlr9M9Btlr
Genetic
Background		 C57BL/6J-Tlr9M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M9Btlr mutation (0 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:220063 )
• mice with this mutation exhibit decreased TNFalpha secretion in response to the TLR9 ligand CpG oligodeoxynucleotide; secretion is lower in homozygous than in heterozygous mutant mice.




Genotype
MGI:5632143
ht2
Allelic
Composition		 Tlr9M9Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M9Btlr mutation (0 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:220063 )
• mice with this mutation exhibit decreased TNFalpha secretion in response to the TLR9 ligand CpG oligodeoxynucleotide; secretion in heterozygous mutant mice is intermediate between that of wild-type and homozygous mutants.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory