Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rhbdf2M3Btlr mutation 3, Bruce Beutler MGI:5632144 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice with this mutation exhibit reduced TNFalpha secretion in response to the TLR ligands LPS (TLR4), Pam3CSK4 (TLR1/2) and R848 (TLR7/8); secretion is lower in homozygous than in heterozgygous mutant mice.
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice with this mutation exhibit reduced TNFalpha secretion in response to the TLR ligands LPS (TLR4), Pam3CSK4 (TLR1/2) and R848 (TLR7/8); secretion in heterozygous mutant mice is intermediate between that in wild-type and homozygous mutant mice.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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