Phenotypes associated with this allele

• Allele Symbol: Il22^{tm1.1(icre)Stck}
• Allele Name: targeted mutation 1.1, Brigitta Stockinger
• Allele ID: MGI:5632146
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il22^tm1.1(icre)Stck/Il22^tm1.1(icre)Stck	involves: 129X1/SvJ * C57BL/6N	MGI:5634194
cn2	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^+ Il22^tm1.1(icre)Stck/Il22^+	involves: 129X1/SvJ * C57BL/6N	MGI:5634193

Genotype
MGI:5634194

cn1

• Allelic Composition: Il22^{tm1.1(icre)Stck}/Il22^{tm1.1(icre)Stck}
• Genetic Background: involves: 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:220074 )

• mice infected with Citrobacter exhibit expanded infection and fail to control Citrobacter compared with control mice

Genotype
MGI:5634193

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺; Il22^{tm1.1(icre)Stck}/Il22⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6N

immune system

abnormal susceptibility to bacterial infection ( J:220074 )

• mice infected with Citrobacter exhibit increased transient weight loss compared with wild-type mice and mice heterozygous for a knock-out allele

• however, mice exhibit normal clearance and kinetics of infection

growth/size/body

increased susceptibility to weight loss ( J:220074 )

• mice infected with Citrobacter exhibit increased transient weight loss compared with wild-type mice and mice heterozygous for a knock-out allele

• however, mice exhibit normal clearance and kinetics of infection