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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf13bM1Btlr
mutation 1, Bruce Beutler
MGI:5632166
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfsf13bM1Btlr/Tnfsf13bM1Btlr C57BL/6J-Tnfsf13bM1Btlr MGI:5632167
ht2
 		Tnfsf13bM1Btlr/Tnfsf13b+ C57BL/6J-Tnfsf13bM1Btlr MGI:5632171


Genotype
MGI:5632167
hm1
Allelic
Composition		 Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic
Background		 C57BL/6J-Tnfsf13bM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13bM1Btlr mutation (0 available); any Tnfsf13b mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:220069 )
• decreased numbers of B cells in peripheral blood.
• reduced frequency of IgM+ B cells in the periphery.
• reduced frequency of peripheral IgD+ B cells.
increased T cell number ( J:220069 )
• in the peripheral blood.
increased single-positive T cell number ( J:220069 )
• increased frequency of CD8+ T cells in the periphery.
decreased IgG level ( J:220069 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).
decreased IgM level ( J:220069 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

immune system
decreased B cell number ( J:220069 )
• decreased numbers of B cells in peripheral blood.
• reduced frequency of IgM+ B cells in the periphery.
• reduced frequency of peripheral IgD+ B cells.
increased T cell number ( J:220069 )
• in the peripheral blood.
increased single-positive T cell number ( J:220069 )
• increased frequency of CD8+ T cells in the periphery.
decreased IgG level ( J:220069 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).
decreased IgM level ( J:220069 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).
impaired humoral immune response ( J:220069 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).




Genotype
MGI:5632171
ht2
Allelic
Composition		 Tnfsf13bM1Btlr/Tnfsf13b+
Genetic
Background		 C57BL/6J-Tnfsf13bM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13bM1Btlr mutation (0 available); any Tnfsf13b mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:220069 )
• decreased numbers of B cells in peripheral blood.
• reduced frequency of IgM+ B cells in the periphery.
• reduced frequency of peripheral IgD+ B cells.
increased T cell number ( J:220069 )
• in the peripheral blood.
increased single-positive T cell number ( J:220069 )
• increased frequency of CD8+ T cells in the periphery.
decreased IgG level ( J:220069 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).
decreased IgM level ( J:220069 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

immune system
decreased B cell number ( J:220069 )
• decreased numbers of B cells in peripheral blood.
• reduced frequency of IgM+ B cells in the periphery.
• reduced frequency of peripheral IgD+ B cells.
increased T cell number ( J:220069 )
• in the peripheral blood.
increased single-positive T cell number ( J:220069 )
• increased frequency of CD8+ T cells in the periphery.
decreased IgG level ( J:220069 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).
decreased IgM level ( J:220069 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).
impaired humoral immune response ( J:220069 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).




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12/10/2024
MGI 6.24 		The Jackson Laboratory