All Phenotypes Tnfsf13b<m2Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfsf13b^m2Btlr
mutation 2, Bruce Beutler
MGI:5632172

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf13b^m2Btlr/Tnfsf13b^m2Btlr	C57BL/6J-Tnfsf13b^m2Btlr	MGI:5632185

Allelic Composition	Tnfsf13b^m2Btlr/Tnfsf13b^m2Btlr
Genetic Background	C57BL/6J-Tnfsf13b^m2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13b^m2Btlr mutation (0 available); any Tnfsf13b mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:220070 )

• reduced B cell to T cell ratio in peripheral blood.

decreased IgG level ( J:220070 )

• diminished T cell-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).

immune system

decreased B cell number ( J:220070 )

• reduced B cell to T cell ratio in peripheral blood.

decreased IgG level ( J:220070 )

• diminished T cell-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).

impaired humoral immune response ( J:220070 )

• diminished T cell-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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