All Phenotypes Nlrp3<M9Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlrp3^M9Btlr
mutation 9, Bruce Beutler
MGI:5632190

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp3^M9Btlr/Nlrp3^M9Btlr	C57BL/6J-Nlrp3^M9Btlr	MGI:5632191
ht2	Nlrp3^M9Btlr/Nlrp3⁺	C57BL/6J-Nlrp3^M9Btlr	MGI:5632192

Allelic Composition	Nlrp3^M9Btlr/Nlrp3^M9Btlr
Genetic Background	C57BL/6J-Nlrp3^M9Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^M9Btlr mutation (0 available); any Nlrp3 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:220071 )

• decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment.

Allelic Composition	Nlrp3^M9Btlr/Nlrp3⁺
Genetic Background	C57BL/6J-Nlrp3^M9Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^M9Btlr mutation (0 available); any Nlrp3 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:220071 )

• decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment; heterozygous mutants exhibit a slightly intermediate phenotype compared to homozygous and wild-type mice, but the mutation was mapped as dominantly inherited.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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