About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3M9Btlr
mutation 9, Bruce Beutler
MGI:5632190
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3M9Btlr/Nlrp3M9Btlr C57BL/6J-Nlrp3M9Btlr MGI:5632191
ht2
 		Nlrp3M9Btlr/Nlrp3+ C57BL/6J-Nlrp3M9Btlr MGI:5632192


Genotype
MGI:5632191
hm1
Allelic
Composition		 Nlrp3M9Btlr/Nlrp3M9Btlr
Genetic
Background		 C57BL/6J-Nlrp3M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M9Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:220071 )
• decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment.




Genotype
MGI:5632192
ht2
Allelic
Composition		 Nlrp3M9Btlr/Nlrp3+
Genetic
Background		 C57BL/6J-Nlrp3M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M9Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:220071 )
• decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment; heterozygous mutants exhibit a slightly intermediate phenotype compared to homozygous and wild-type mice, but the mutation was mapped as dominantly inherited.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory