Phenotypes associated with this allele

• Allele Symbol: Pax5^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5632194
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax5^m1Btlr/Pax5^m1Btlr	C57BL/6J-Pax5^m1Btlr	MGI:5632196

Genotype
MGI:5632196

hm1

• Allelic Composition: Pax5^m1Btlr/Pax5^m1Btlr
• Genetic Background: C57BL/6J-Pax5^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:220072 )

• Fluorescence activated cell sorting (FACS) of peripheral blood from homozygous mutant mice demonstrated significant depletion of B cells.

increased T cell number ( J:220072 )

• FACS analysis of peripheral blood demonstrated a significant increase in the proportion of T cells.

increased single-positive T cell number ( J:220072 )

• FACS analysis showed increased proportions of CD4⁺ and CD8⁺ T cells in the peripheral blood.

increased macrophage cell number ( J:220072 )

• demonstrated by FACS analysis of peripheral blood.

increased monocyte cell number ( J:220072 )

• demonstrated by FACS analysis of peripheral blood.

decreased IgA level ( J:220072 )

decreased IgG level ( J:220072 )

• diminished unstimulated serum IgG levels.

• diminished T cell-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• diminished T cell-dependent antibody response to ovalbumin administered with aluminum hydroxide.

decreased IgG1 level ( J:220072 )

decreased IgG2a level ( J:220072 )

decreased IgG2b level ( J:220072 )

decreased IgM level ( J:220072 )

• reduced levels of unstimulated serum IgM.

• diminished T cell-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

immune system

decreased B cell number ( J:220072 )

• Fluorescence activated cell sorting (FACS) of peripheral blood from homozygous mutant mice demonstrated significant depletion of B cells.

increased T cell number ( J:220072 )

• FACS analysis of peripheral blood demonstrated a significant increase in the proportion of T cells.

increased single-positive T cell number ( J:220072 )

• FACS analysis showed increased proportions of CD4⁺ and CD8⁺ T cells in the peripheral blood.

increased macrophage cell number ( J:220072 )

• demonstrated by FACS analysis of peripheral blood.

increased monocyte cell number ( J:220072 )

• demonstrated by FACS analysis of peripheral blood.

decreased IgA level ( J:220072 )

decreased IgG level ( J:220072 )

• diminished unstimulated serum IgG levels.

• diminished T cell-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• diminished T cell-dependent antibody response to ovalbumin administered with aluminum hydroxide.

decreased IgG1 level ( J:220072 )

decreased IgG2a level ( J:220072 )

decreased IgG2b level ( J:220072 )

decreased IgM level ( J:220072 )

• reduced levels of unstimulated serum IgM.

• diminished T cell-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

impaired humoral immune response ( J:220072 )

• diminished T cell-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

• diminished T cell-dependent antibody response to ovalbumin administered with aluminum hydroxide.

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)