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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il1r1tm1Quan
targeted mutation 1, Ning Quan
MGI:5633953
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il1r1tm1Quan/Il1r1tm1Quan involves: C57BL/6 MGI:5634706
cn2
 		Il1r1tm1Quan/Il1r1tm1Quan
Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo 		involves: 129P2/OlaHsd * C57BL/6 MGI:5638893
cn3
 		Il1r1tm1Quan/Il1r1tm1Quan
Tg(Tek-cre)12Flv/0 		involves: C3H * C57BL/6 MGI:5634707


Genotype
MGI:5634706
hm1
Allelic
Composition		 Il1r1tm1Quan/Il1r1tm1Quan
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Quan mutation (1 available); any Il1r1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal microglial cell activation ( J:219864 )
• microglia remain in unstimulated resting stage (ramified morphology) following IL1beta injection

immune system
abnormal microglial cell activation ( J:219864 )
• microglia remain in unstimulated resting stage (ramified morphology) following IL1beta injection
abnormal inflammatory response ( J:219864 )
• intracerebroventricular IL1beta injection does not result in leukocyte infiltration to the brain parenchyma in contrast to wild-type controls

nervous system
abnormal microglial cell activation ( J:219864 )
• microglia remain in unstimulated resting stage (ramified morphology) following IL1beta injection




Genotype
MGI:5638893
cn2
Allelic
Composition		 Il1r1tm1Quan/Il1r1tm1Quan
Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Quan mutation (1 available); any Il1r1 mutation (39 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal microglial cell activation ( J:219864 )
• microglia are only activated (deramified) in hippocampus region following IL1beta injection rather than throughout the brain parenchyma

immune system
abnormal microglial cell activation ( J:219864 )
• microglia are only activated (deramified) in hippocampus region following IL1beta injection rather than throughout the brain parenchyma
abnormal inflammatory response ( J:219864 )
• intracerebroventricular IL1beta injection does not result in leukocyte infiltration to the brain parenchyma in contrast to wild-type controls

nervous system
abnormal microglial cell activation ( J:219864 )
• microglia are only activated (deramified) in hippocampus region following IL1beta injection rather than throughout the brain parenchyma




Genotype
MGI:5634707
cn3
Allelic
Composition		 Il1r1tm1Quan/Il1r1tm1Quan
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Quan mutation (1 available); any Il1r1 mutation (39 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal microglial cell activation ( J:219864 )
• microglia are activated (deramified) throughout the brain prenchyma following IL1beta injection

immune system
abnormal microglial cell activation ( J:219864 )
• microglia are activated (deramified) throughout the brain prenchyma following IL1beta injection
abnormal inflammatory response ( J:219864 )
• intracerebroventricular IL1beta administration results in leukocyte infiltration (CD45+ cell trafficking) to the brain parenchyma 12 hours after injection

nervous system
abnormal microglial cell activation ( J:219864 )
• microglia are activated (deramified) throughout the brain prenchyma following IL1beta injection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory