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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps
transgene insertion, David M Spencer
MGI:5633983
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp/0
Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/0 		involves: FVB/N MGI:5633988
tg2
 		Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/0 involves: FVB/N MGI:5633986


Genotype
MGI:5633988
cx1
Allelic
Composition		 Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp/0
Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland adenocarcinoma incidence ( J:206727 )
• mice develop adenocarcinoma by 24 weeks after treatment with a chemical inducer of dimerization, AP20187
• however, tumors do not progress until 60 weeks of AP20187 treatment

reproductive system
increased prostate gland adenocarcinoma incidence ( J:206727 )
• mice develop adenocarcinoma by 24 weeks after treatment with a chemical inducer of dimerization, AP20187
• however, tumors do not progress until 60 weeks of AP20187 treatment

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:206727 )
• mice develop adenocarcinoma by 24 weeks after treatment with a chemical inducer of dimerization, AP20187
• however, tumors do not progress until 60 weeks of AP20187 treatment




Genotype
MGI:5633986
tg2
Allelic
Composition		 Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
prostate gland hyperplasia ( J:206727 )
• mice only show minor prostate hyperplasia after treatment with a chemical inducer of dimerization, AP20187

reproductive system
prostate gland hyperplasia ( J:206727 )
• mice only show minor prostate hyperplasia after treatment with a chemical inducer of dimerization, AP20187




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory