Phenotypes associated with this allele

• Allele Symbol: Prlh^tm1(cre)Smln
• Allele Name: targeted mutation 1, Simon M Luckman
• Allele ID: MGI:5634277
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lepr^tm1.1Chua/Lepr^tm1.1Chua Prlh^tm1(cre)Smln/Prlh^+	involves: 129 * C57BL/6J	MGI:5634284

Genotype
MGI:5634284

cn1

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Prlh^tm1(cre)Smln/Prlh⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:215557 )

• at 16 weeks

increased circulating leptin level ( J:215557 )

• at 16, but not 6, weeks

decreased core body temperature ( J:215557 )

• slightly over a 24 hour period

abnormal body temperature homeostasis ( J:215557 )

• at 6 weeks, mice treated with leptin fails to increase core body temperature unlike wild-type mice

decreased energy expenditure ( J:215557 )

decreased oxygen consumption ( J:215557 )

• at 8 to 10 weeks

abnormal response/metabolism to endogenous compounds ( J:215557 )

• at 6 weeks, mice treated with leptin fails to increase core body temperature unlike wild-type mice

• at 6 weeks, mice treated with leptin fail to exhibit an increase core body temperature and exhibit an attenuated reduction in night-time feeding compared with wild-type mice

• however, mice respond to the satiating effect of Cck normally

growth/size/body

increased body weight ( J:215557 )

• at 16 weeks

obese ( J:215557 )

• late-onset at 16 weeks

adipose tissue

increased subcutaneous adipose tissue amount ( J:215557 )

• at 16 weeks

increased epididymal fat pad weight ( J:215557 )

• at 16 weeks

behavior/neurological

behavior/neurological phenotype ( J:215557 )

N • mice exhibit normal food intake and respond to the satiating effect of Cck normally

integument

increased subcutaneous adipose tissue amount ( J:215557 )

• at 16 weeks