Analysis Tools
behavior/neurological
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• 9 month old mice show impairment in spatial memory in the Morris water maze, needing more time to reach the hidden platform
• mice, however do not exhibit differences in basal activities up to 18 months of age
• oral administration of hop flower extract improves spatial memory
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• at 18 months of age, mutants show longer times away form the walls in the open field, indicating impairment in feeling anxiety
• oral administration of hop flower extract prevents the disturbance seen in the open field
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homeostasis/metabolism
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• amyloid beta deposits are seen in the parietal lobe of the cerebral cortex
• oral administration of hop flower extract reduces amyloid beta deposits
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• amyloid angiopathy is seen around certain artery walls
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nervous system
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• amyloid beta deposits are seen in the parietal lobe of the cerebral cortex
• oral administration of hop flower extract reduces amyloid beta deposits
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• amyloid angiopathy is seen around certain artery walls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:212692 | ||
