Phenotypes associated with this allele

• Allele Symbol: Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz
• Allele Name: transgene insertion, Akira Kakizuka
• Allele ID: MGI:5634331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz/0	involves: C57BL/6	MGI:5634333

Genotype
MGI:5634333

tg1

• Allelic Composition: Tg(Eno2-APP*Ind,-PSEN1*P267S)#Kakiz/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:212692 )

• 9 month old mice show impairment in spatial memory in the Morris water maze, needing more time to reach the hidden platform

• in the probe test, mutants spent a similar amount of time around the area where the hidden platform had been compared to time spent in the other areas unlike wild-type mice which spend more time around the area where the hidden platform had been placed

• 9 month old mutants show impaired spatial memory in a Y-maze test

• oral administration of hop flower extract improves spatial memory