Analysis Tools
behavior/neurological
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• withdrawal of doxycycline after administrating it for the first three weeks of life results in hypoactivity from 6 weeks of age
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• in the absence of doxycycline, mice show spontaneous behavioral seizures around 2 weeks of age accompanied by abnormal local field potentials
• mice exhibit frequent spontaneous seizures 3-4 weeks after withdrawal of doxycycline; seizures are characterized by unilateral forelimb clonus followed by bilateral forelimb clonus and falling, and differences in local field potentials between the right and left cortices
• administration of doxycycline or rapamycin suppresses epileptic seizures
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growth/size/body
megacephaly
(
J:211789
)
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• in the absence of doxycycline, mice show macrocephaly with abnormal cortical cytoarchitecture
• withdrawal of doxycycline after administrating it for the first three weeks of life results is macrocephaly without affecting the arrangement of the cortical layer
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• in the absence of doxycycline, mice exhibit severe growth retardation from P10
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hematopoietic system
microgliosis
(
J:211789
)
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• in the absence of doxycycline, mice exhibit an increased number of microglial cells with enlarged cell bodies and short processes in the cortex
• withdrawal of doxycycline after administrating it for the first three weeks of life results in an increased number of microglial cells with enlarged cell bodies and short processes
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immune system
microgliosis
(
J:211789
)
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• in the absence of doxycycline, mice exhibit an increased number of microglial cells with enlarged cell bodies and short processes in the cortex
• withdrawal of doxycycline after administrating it for the first three weeks of life results in an increased number of microglial cells with enlarged cell bodies and short processes
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mortality/aging
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• withdrawal of doxycline after administrating it for the first three weeks of life results is death between 6 and 7 weeks of age
• administration of doxycycline or rapamycin suppresses lethality
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• in the absence of doxycycline, mice die at 15-20 days of age
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nervous system
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• in the absence of doxycycline, mice show spontaneous behavioral seizures around 2 weeks of age accompanied by abnormal local field potentials
• mice exhibit frequent spontaneous seizures 3-4 weeks after withdrawal of doxycycline; seizures are characterized by unilateral forelimb clonus followed by bilateral forelimb clonus and falling, and differences in local field potentials between the right and left cortices
• administration of doxycycline or rapamycin suppresses epileptic seizures
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microgliosis
(
J:211789
)
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• in the absence of doxycycline, mice exhibit an increased number of microglial cells with enlarged cell bodies and short processes in the cortex
• withdrawal of doxycycline after administrating it for the first three weeks of life results in an increased number of microglial cells with enlarged cell bodies and short processes
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• cortical hypertrophy is seen at P12 in the absence of doxycycline
• in the absence of doxycycline, cortical lamination is disrupted
• withdrawal of doxycycline after administrating it for the first three weeks of life results in cortical hypertrophy at 6-7 weeks of age, however, cortical lamination is preserved
• administration of doxycycline or rapamycin suppresses cortical hypertrophy
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• in the absence of doxycycline, cortical thickness is increased
• withdrawal of doxycycline after administrating it for the first three weeks of life results in thickened cerebral cortex at 6-7 weeks of age
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• in the absence of doxycycline, soma size of cortical neurons is increased
• withdrawal of doxycycline after administrating it for the first three weeks of life results in enlarged cortical neuronal soma at 6-7 weeks of age
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• in the absence of doxycycline, mice exhibit an accumulation of ubiquitin-positive inclusions in neurons of the cortex at P2
• withdrawal of doxycycline after administrating it for the first three weeks of life results in ubiquitin-positive cytoplasmic inclusions in many neurons of the cortex, specially in the pyramidal neurons in layers II/III and V
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• mice exhibit neurodegeneration after doxycycline removal
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