Phenotypes associated with this allele

• Allele Symbol: Dbr1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5635044
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dbr1^tm1.1(KOMP)Vlcg/Dbr1^tm1.1(KOMP)Vlcg	B6N(Cg)-Dbr1^tm1.1(KOMP)Vlcg/J	MGI:6262252
ht2	Dbr1^tm1.1(KOMP)Vlcg/Dbr1^+	B6N(Cg)-Dbr1^tm1.1(KOMP)Vlcg/J	MGI:6262251

Genotype
MGI:6262252

hm1

• Allelic Composition: Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Dbr1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18796A-G12

Data Sources

IMPC Data for Dbr1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and generate typical outgrowth colonies.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• normal looking blastocysts are present at E3.5 (19% versus expected 25%, n=54); no homozygous embryos or excess resorption sites are observed at E7.5

• in vitro, blastocysts hatch from the zona pellucida and form morphologically typical outgrowth colonies with apparent trophectoderm (TE), primitive endoderm (PrE) and inner cell mass (ICM) after 3 days in culture

Genotype
MGI:6262251

ht2

• Allelic Composition: Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1⁺
• Genetic Background: B6N(Cg)-Dbr1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18796A-G12

Data Sources

IMPC Data for Dbr1

homeostasis/metabolism

decreased urine magnesium level ( J:211773 )

IMPC - JAX

renal/urinary system

decreased urine magnesium level ( J:211773 )

IMPC - JAX

vision/eye

abnormal lens morphology ( J:211773 )

♀

IMPC - JAX