mortality/aging
• normal looking blastocysts are present in slightly lower than expected Mendelian ratios at E3.5 (19% versus 25%); no homozygous embryos or excess resorption sites are observed at E7.5
• however, blastocysts hatch from the zona pellucida and form morphologically typical outgrowth colonies with apparent trophectoderm (TE), primitive endoderm (PrE) and inner cell mass (ICM) after 3 days in culture
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