Phenotypes associated with this allele

• Allele Symbol: Mpc2^em2Finc
• Allele Name: endonuclease-mediated mutation 2, Brian Finck
• Allele ID: MGI:5635078
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpc2^em2Finc/Mpc2^em2Finc	involves: C57BL/6	MGI:6202414

Genotype
MGI:6202414

hm1

• Allelic Composition: Mpc2^em2Finc/Mpc2^em2Finc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:211781 )

N • unlike mice homozygous for a null allele, mice homozygous for a truncated allele are born at the expected numbers

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:211781 )

N • exercise endurance is similar to controls

N • hepatic gluconeogenesis is not impaired

decreased insulin secretion ( J:211781 )

• impaired glucose-stimulated insulin secretion in isolated pancreatic islets

increased circulating glucose level ( J:211781 )

• significantly greater blood glucose excursion following pyruvate injection

decreased circulating insulin level ( J:211781 )

• at baseline and 30 minutes after glucose injection

increased circulating ketone body level ( J:211781 )

increased circulating lactate level ( J:211781 )

• increased lactate levels

• following pyruvate injection the decline in blood lactate is slower compared to wild-type controls

• during a glucose tolerance test, blood lactate levels are increased

decreased circulating triglyceride level ( J:211781 )

decreased oxygen consumption ( J:211781 )

• 25%-30% lower rates of pyruvate/malate-stimulated respiration in isolated mitochondria in 2,4-dinitrophenol-uncoupled conditions compared to mitochondria from wild-type mice

• addition of methyl-pyruvate rescues oxygen consumption and maximal oxygen consumption with glutamate/malate or succinate/rotenone are similar to controls

impaired glucose tolerance ( J:211781 )

cellular

abnormal mitochondrial physiology ( J:211781 )

• increased 13C-labeled plasma lactate levels indicate decreased mitochondrial pyruvate metabolism in extrahepatic tissues

endocrine/exocrine glands

decreased insulin secretion ( J:211781 )

• impaired glucose-stimulated insulin secretion in isolated pancreatic islets