Phenotypes associated with this allele

• Allele Symbol: Gpc4^{tm2b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5635154
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpc4^tm2b(EUCOMM)Wtsi/Gpc4^tm2b(EUCOMM)Wtsi	C57BL/6N-Gpc4^tm2b(EUCOMM)Wtsi/J	MGI:6461306
ot2	Gpc4^tm2b(EUCOMM)Wtsi/Y	C57BL/6N-Gpc4^tm2b(EUCOMM)Wtsi/J	MGI:6480468

Genotype
MGI:6461306

hm1

• Allelic Composition: Gpc4^{tm2b(EUCOMM)Wtsi}/Gpc4^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Gpc4^{tm2b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0430_5_E03

Data Sources

IMPC Data for Gpc4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - JAX

craniofacial

abnormal snout morphology ( J:211773 )

♀

IMPC - JAX

growth/size/body

abnormal snout morphology ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - JAX

abnormal cholesterol homeostasis ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:6480468

ot2

• Allelic Composition: Gpc4^{tm2b(EUCOMM)Wtsi}/Y
• Genetic Background: C57BL/6N-Gpc4^{tm2b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0430_5_E03

Data Sources

IMPC Data for Gpc4

hematopoietic system

increased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - JAX

increased mean corpuscular hemoglobin concentration ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♂

IMPC - JAX

decreased blood urea nitrogen level ( J:211773 )

♂

IMPC - JAX

increased circulating bilirubin level ( J:211773 )

♂

IMPC - JAX

decreased fasting circulating glucose level ( J:211773 )

♂

IMPC - JAX

vision/eye

cornea opacity ( J:211773 )

♂

IMPC - JAX