All Phenotypes Nr2f1<tm1.1(KOMP)Mbp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr2f1^{tm1.1(KOMP)Mbp}
targeted mutation 1.1, Mouse Biology Program, UC Davis
MGI:5635253

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr2f1^{tm1.1(KOMP)Mbp}/Nr2f1^{tm1.1(KOMP)Mbp}	C57BL/6N-Nr2f1^{tm1.1(KOMP)Mbp}/J	MGI:6263046
ht2	Nr2f1^{tm1.1(KOMP)Mbp}/Nr2f1⁺	C57BL/6N-Nr2f1^{tm1.1(KOMP)Mbp}/J	MGI:6288608
cx3	Mctp1^dwnd/Nr2f1^{tm1.1(KOMP)Mbp}	involves: C57BL/6J * C57BL/6NJ * C57BL/10SnJ	MGI:6197582

Allelic Composition	Nr2f1^{tm1.1(KOMP)Mbp}/Nr2f1^{tm1.1(KOMP)Mbp}
Genetic Background	C57BL/6N-Nr2f1^{tm1.1(KOMP)Mbp}/J
Cell Lines	DEPD00542_3_B09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1^{tm1.1(KOMP)Mbp} mutation (1 available); any Nr2f1 mutation (25 available)

Data Sources

IMPC Data for Nr2f1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:211773 )

IMPC - JAX

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Allelic Composition	Nr2f1^{tm1.1(KOMP)Mbp}/Nr2f1⁺
Genetic Background	C57BL/6N-Nr2f1^{tm1.1(KOMP)Mbp}/J
Cell Lines	DEPD00542_3_B09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2f1^{tm1.1(KOMP)Mbp} mutation (1 available); any Nr2f1 mutation (25 available)

Data Sources

IMPC Data for Nr2f1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - JAX

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - JAX

Allelic Composition	Mctp1^dwnd/Nr2f1^{tm1.1(KOMP)Mbp}
Genetic Background	involves: C57BL/6J * C57BL/6NJ * C57BL/10SnJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mctp1^dwnd mutation (1 available); any Mctp1 mutation (58 available)
Nr2f1^{tm1.1(KOMP)Mbp} mutation (1 available); any Nr2f1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell morphology ( J:264553 )

• basal cochlea has disorganized hair cells and an excess of inner hair cells, and the apex has extra rows of outer hair cells

abnormal cochlear inner hair cell morphology ( J:264553 )

abnormal cochlear outer hair cell morphology ( J:264553 )

short scala media ( J:264553 )

abnormal utricular macula morphology ( J:264553 )

• the utricular macula is reduced from an ovate to a trapezoid shape

abnormal vestibular saccular macula morphology ( J:264553 )

• the saccular macula is often attached to the utricular macula and cochlear base

fused vestibular saccule and utricle ( J:264553 )

• the utricle and saccule fail to properly separate

increased or absent threshold for auditory brainstem response ( J:264553 )

• transheterozygotes have ABR thresholds 25-50 dB higher than controls at 1 month of age

impaired hearing ( J:264553 )

nervous system

abnormal cochlear hair cell morphology ( J:264553 )

• basal cochlea has disorganized hair cells and an excess of inner hair cells, and the apex has extra rows of outer hair cells

abnormal cochlear inner hair cell morphology ( J:264553 )

abnormal cochlear outer hair cell morphology ( J:264553 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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