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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif21atm3Ece
targeted mutation 3, Elizabeth C Engle
MGI:5635266
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif21atm3Ece/Kif21atm3Ece involves: 129S1/Sv MGI:6241437
ht2
 		Kif21atm3Ece/Kif21a+ involves: 129S1/Sv MGI:6241438
ht3
 		Kif21atm1.1Ece/Kif21atm3Ece involves: 129S1/Sv * 129S4/SvJae MGI:6241442


Genotype
MGI:6241437
hm1
Allelic
Composition		 Kif21atm3Ece/Kif21atm3Ece
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21atm3Ece mutation (0 available); any Kif21a mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:213171 )
• mice die within 24 hours of birth

nervous system
nervous system phenotype ( J:213171 )
N
• the developing oculomotor nerve does not contain a bulb or distal thinning and oculomotor nerve neuron apoptosis is similar to wild-type levels




Genotype
MGI:6241438
ht2
Allelic
Composition		 Kif21atm3Ece/Kif21a+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21atm3Ece mutation (0 available); any Kif21a mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:213171 )
• mice are viable and appear phenotypically normal, with no external congenital fibrosis of the extraocular muscles phenotype




Genotype
MGI:6241442
ht3
Allelic
Composition		 Kif21atm1.1Ece/Kif21atm3Ece
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21atm1.1Ece mutation (0 available); any Kif21a mutation (81 available)
Kif21atm3Ece mutation (0 available); any Kif21a mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal extraocular muscle morphology ( J:213171 )
• 22% of mice show an external congenital fibrosis of the extraocular muscles phenotype that is mild

muscle
abnormal extraocular muscle morphology ( J:213171 )
• 22% of mice show an external congenital fibrosis of the extraocular muscles phenotype that is mild




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory