Phenotypes associated with this allele

• Allele Symbol: Ip6k2^tm1.1Snyd
• Allele Name: targeted mutation 1.1, Solomon Snyder
• Allele ID: MGI:5635272
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ip6k2^tm1.1Snyd/Ip6k2^tm1.1Snyd	B6.129-Ip6k2^tm1.1Snyd	MGI:5698377

Genotype
MGI:5698377

hm1

• Allelic Composition: Ip6k2^tm1.1Snyd/Ip6k2^tm1.1Snyd
• Genetic Background: B6.129-Ip6k2^tm1.1Snyd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:212482 )

• following treatment with neocarzinostatin, which elicits double-stranded DNA breaks that mimic effects of ionizing radiation, mutant B cells display reduced Trp53 phosphorylation and increased cell viability relative to similarly-treated wild-type B cells

decreased cellular sensitivity to ionizing radiation ( J:212482 )

• following exposure to ionizing radiation (2G or 5 G), mutant B cells show increased viability relative to similarly-treated wild-type B cells

hematopoietic system

abnormal B cell physiology ( J:212482 )

• mutant resting B cells show markedly reduced expression of DNA-PKcs and ATM, which are phosphoinositide-3-kinaserelated-kinases (PIKKs) shown to mediate the phosphorylation and apoptotic actions of Trp53

• in contrast, mutant MEFs show no alterations in levels of DNA-PKcs or ATM relative to wild-type MEFs

immune system

abnormal B cell physiology ( J:212482 )

• mutant resting B cells show markedly reduced expression of DNA-PKcs and ATM, which are phosphoinositide-3-kinaserelated-kinases (PIKKs) shown to mediate the phosphorylation and apoptotic actions of Trp53

• in contrast, mutant MEFs show no alterations in levels of DNA-PKcs or ATM relative to wild-type MEFs