Phenotypes associated with this allele

• Allele Symbol: Mzb1^tm1.2Rug
• Allele Name: targeted mutation 1.2, Rudolf Grosschedl
• Allele ID: MGI:5636602
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mzb1^tm1.2Rug/Mzb1^tm1.2Rug	involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL	MGI:6294904

Genotype
MGI:6294904

hm1

• Allelic Composition: Mzb1^tm1.2Rug/Mzb1^tm1.2Rug
• Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:211639 )

N • normal frequencies of CD19+ B cells (including CD19+ AA4.1+ immature B cells), CD21int CD23+ follicular B and CD21hi CD23- MZ B cells, peritoneal B-1a and B-1b cells, and normal B220+ CD43+ pro-B-cell and B220int CD43- pre-B-cell compartments in the bone marrow

N • equal proportion of wild-type and mutant splenic B cells in competitive bone marrow reconstitution experiments

increased pro-B cell number ( J:211639 )

• increased percentage of bone marrow B220+ CD43- pro-B cells after intraperitoneal tunicamycin administration

decreased pre-B cell number ( J:211639 )

• significant reduction in bone marrow B220in CD43- pre-B cell compartment after intraperitoneal tunicamycin administration

immune system

immune system phenotype ( J:211639 )

N • normal frequencies of CD19+ B cells (including CD19+ AA4.1+ immature B cells), CD21int CD23+ follicular B and CD21hi CD23- MZ B cells, peritoneal B-1a and B-1b cells, and normal B220+ CD43+ pro-B-cell and B220int CD43- pre-B-cell compartments in the bone marrow

N • equal proportion of wild-type and mutant splenic B cells in competitive bone marrow reconstitution experiments

N • normal IgM surface expression

N • normal frequency of mature splenic B cells after intraperitoneal tunicamycin administration

N • normal frequency of recirculating B220hi CD43- B cells after intraperitoneal tunicamycin administration

increased pro-B cell number ( J:211639 )

• increased percentage of bone marrow B220+ CD43- pro-B cells after intraperitoneal tunicamycin administration

decreased pre-B cell number ( J:211639 )

• significant reduction in bone marrow B220in CD43- pre-B cell compartment after intraperitoneal tunicamycin administration

impaired humoral immune response ( J:211639 )

• significantly reduced immune response after intravenous challenge with T-cell-independent type 2 (TI-2) antigen TNP-Ficoll or Streptococcus pneumoniae type 3 polysaccharide

• reduced amounts of anti-TNP-specific IgG3 isotype antibodies after intravenous challenge with TI-2 antigen TNP-Ficoll