Analysis Tools
neoplasm
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• mice develop diffuse, large-cell lymphomas involving spleen, lymph nodes, liver, thymus, bone marrow, kidney, lung, meninges and skin
• perivascular infiltration of lymphomatous cells are seen in the liver, kidney, and lungs
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• presence of large and abnormal leukemic cells with cleaved nuclei identical to flower cells seen in adult T-cell leukemia-lymphoma (ATLL)
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endocrine/exocrine glands
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• mice develop diffuse, large-cell lymphomas involving spleen, lymph nodes, liver, thymus, bone marrow, kidney, lung, meninges and skin
• perivascular infiltration of lymphomatous cells are seen in the liver, kidney, and lungs
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growth/size/body
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• mice develop hepatomegaly beginning at 10 months of age
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• mice develop splenomegaly beginning at 10 months of age
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• hepatosplenomegaly with a 5-20-fold increase in organ size
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immune system
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• mice develop splenomegaly beginning at 10 months of age
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• hepatosplenomegaly with a 5-20-fold increase in organ size
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• mice develop lymphadenopathy beginning at 10 months of age
• lymphadenopathy is most often seen in the mesenteric, cervical and axillary lymph nodes and sometimes inguinal nodes
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• mice develop severe pulmonary infections with P.jiroveci
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liver/biliary system
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• mice develop hepatomegaly beginning at 10 months of age
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• hepatosplenomegaly with a 5-20-fold increase in organ size
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hematopoietic system
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• mice develop splenomegaly beginning at 10 months of age
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• hepatosplenomegaly with a 5-20-fold increase in organ size
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| T-cell adult acute lymphocytic leukemia | DOID:5602 | J:129531 , J:214623 | ||
