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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srpk1tm1Xdfu
targeted mutation 1, Xiang-Dong Fu
MGI:5636722
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Srpk1tm1Xdfu/Srpk1tm1Xdfu involves: 129 MGI:6379750


Genotype
MGI:6379750
cn1
Allelic
Composition		 Srpk1tm1Xdfu/Srpk1tm1Xdfu
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srpk1tm1Xdfu mutation (0 available); any Srpk1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:213142 )
• MEFs from cre-expressing virus infected mice show retarded cell growth
• however, immortalized MEFs no longer show cell growth arrest and cells show a more potent transformation phenotype
early cellular replicative senescence ( J:213142 )
• MEFs from cre-expressing virus infected mice show premature senescence




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory