Phenotypes associated with this allele

• Allele Symbol: Dok7^tm2Yyam
• Allele Name: targeted mutation 2, Yuji Yamanashi
• Allele ID: MGI:5636724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dok7^tm2Yyam/Dok7^tm2Yyam	involves: 129P2/OlaHsd * C57BL/6J	MGI:5636739

Genotype
MGI:5636739

hm1

• Allelic Composition: Dok7^tm2Yyam/Dok7^tm2Yyam
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:213767 )

• die between P13 and P20

behavior/neurological

abnormal gait ( J:213767 )

• mice develop gait disturbances by P9

growth/size/body

decreased body weight ( J:213767 )

• mice are about 25% of the body weight of wild-type mice at P12

muscle

muscle weakness ( J:213767 )

• severe muscle weakness

nervous system

abnormal neuromuscular synapse morphology ( J:213767 )

• small neuromuscular junctions lacking postsynaptic folding

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital myasthenic syndrome 10		DOID:0110668	OMIM:254300	J:213767