Phenotypes associated with this allele

• Allele Symbol: Oprk1^tm1.2Waca
• Allele Name: targeted mutation 1.2, William A Carlezon Jr
• Allele ID: MGI:5636742
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprk1^tm1.2Waca/Oprk1^tm1.2Waca	B6J.B6NTac(Cg)-Oprk1^tm1.2Waca	MGI:5903636

Genotype
MGI:5903636

hm1

• Allelic Composition: Oprk1^tm1.2Waca/Oprk1^tm1.2Waca
• Genetic Background: B6J.B6NTac(Cg)-Oprk1^tm1.2Waca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:211750 )

♂N • mice exhibit normal general locomotor behavior, normal anxiety in the open field and light/dark box tests, and normal sensitivity to the locomotor-stimulating effects of cocaine relative to control mice

decreased chemically-elicited antinociception ( J:211750 )

♂ • mice are resistant to agonist U50,488-induced analgesia, as shown by a failure to exhibit increased tail withdrawal latencies in the warm water tail-flick assay

♂ • however, baseline tail withdrawal latencies are not significantly altered relative to control mice