Phenotypes associated with this allele

• Allele Symbol: Pdia4^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5636896
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdia4^tm1b(EUCOMM)Wtsi/Pdia4^tm1b(EUCOMM)Wtsi	C57BL/6N-Pdia4^tm1b(EUCOMM)Wtsi/Wtsi	MGI:6263125
cn2	Pdia4^tm1b(EUCOMM)Wtsi/Pdia4^tm1b(EUCOMM)Wtsi Tg(Tek-cre)12Flv/0	involves: C3H * C57BL/6N	MGI:6157438
cn3	Pdia4^tm1b(EUCOMM)Wtsi/Pdia4^tm1b(EUCOMM)Wtsi Tg(Pf4-icre)Q3Rsko/0	involves: C57BL/6N	MGI:6157437

Genotype
MGI:6263125

hm1

• Allelic Composition: Pdia4^{tm1b(EUCOMM)Wtsi}/Pdia4^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pdia4^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0629_2_A03

Data Sources

IMPC Data for Pdia4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - WTSI

increased circulating creatine kinase level ( J:211773 )

♂

IMPC - WTSI

Genotype
MGI:6157438

cn2

• Allelic Composition: Pdia4^{tm1b(EUCOMM)Wtsi}/Pdia4^{tm1b(EUCOMM)Wtsi}; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6N

hematopoietic system

hematopoietic system phenotype ( J:244748 )

N • mice exhibit normal platelet counts and size, prothrombin time, partial thromboplastin time, and fibrinogen levels

decreased platelet aggregation ( J:244748 )

homeostasis/metabolism

decreased platelet aggregation ( J:244748 )

increased bleeding time ( J:244748 )

Genotype
MGI:6157437

cn3

• Allelic Composition: Pdia4^{tm1b(EUCOMM)Wtsi}/Pdia4^{tm1b(EUCOMM)Wtsi}; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: C57BL/6N

hematopoietic system

hematopoietic system phenotype ( J:244748 )

N • mice exhibit normal platelet counts and size and fibrin deposition

decreased platelet ATP level ( J:244748 )

decreased platelet aggregation ( J:244748 )

• induced by thrombin, convulxin or ADP

homeostasis/metabolism

decreased platelet ATP level ( J:244748 )

decreased platelet aggregation ( J:244748 )

• induced by thrombin, convulxin or ADP

cellular

decreased platelet ATP level ( J:244748 )