Phenotypes associated with this allele

• Allele Symbol: Dpm1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5636953
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpm1^tm1b(KOMP)Wtsi/Dpm1^tm1b(KOMP)Wtsi	C57BL/6N-Dpm1^tm1b(KOMP)Wtsi/Wtsi	MGI:5757016
ht2	Dpm1^tm1b(KOMP)Wtsi/Dpm1^+	C57BL/6N-Dpm1^tm1b(KOMP)Wtsi/Wtsi	MGI:5757015

Genotype
MGI:5757016

hm1

• Allelic Composition: Dpm1^{tm1b(KOMP)Wtsi}/Dpm1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dpm1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0585_3_G04

Data Sources

IMPC Data for Dpm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion

abnormal placenta morphology ( J:261316 )

• branching morphology defect

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

increased trophoblast giant cell number ( J:261316 )

• overabundant and enlarged trophoblast giant cells

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - WTSI

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

Genotype
MGI:5757015

ht2

• Allelic Composition: Dpm1^{tm1b(KOMP)Wtsi}/Dpm1⁺
• Genetic Background: C57BL/6N-Dpm1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0585_3_G04

Data Sources

IMPC Data for Dpm1

behavior/neurological

increased grip strength ( J:211773 )

IMPC - WTSI