Phenotypes associated with this allele

• Allele Symbol: Dennd4c^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dennd4c^tm1b(EUCOMM)Wtsi/Dennd4c^tm1b(EUCOMM)Wtsi	C57BL/6N-Dennd4c^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5756981

Genotype
MGI:5756981

hm1

• Allelic Composition: Dennd4c^{tm1b(EUCOMM)Wtsi}/Dennd4c^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Dennd4c^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0842_1_G03

Data Sources

IMPC Data for Dennd4c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• biased differentiation (diploid/polyploid trophoblast)

abnormal visceral yolk sac morphology ( J:261316 )

• yolk sac abnormalities

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - WTSI

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5