Phenotypes associated with this allele

• Allele Symbol: Timmdc1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637083
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timmdc1^tm1b(EUCOMM)Wtsi/Timmdc1^tm1b(EUCOMM)Wtsi	C57BL/6N-Timmdc1^tm1b(EUCOMM)Wtsi/Wtsi	MGI:6263689
ht2	Timmdc1^tm1b(EUCOMM)Wtsi/Timmdc1^+	C57BL/6N-Timmdc1^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5797865

Genotype
MGI:6263689

hm1

• Allelic Composition: Timmdc1^{tm1b(EUCOMM)Wtsi}/Timmdc1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Timmdc1^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0496_1_C09

Data Sources

IMPC Data for Timmdc1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Genotype
MGI:5797865

ht2

• Allelic Composition: Timmdc1^{tm1b(EUCOMM)Wtsi}/Timmdc1⁺
• Genetic Background: C57BL/6N-Timmdc1^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0496_1_C09

Data Sources

IMPC Data for Timmdc1

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - WTSI

integument

abnormal coat appearance ( J:211773 )

♂

IMPC - WTSI