Phenotypes associated with this allele

• Allele Symbol: Nrbp1^{tm3b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 3b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637124
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrbp1^tm3b(EUCOMM)Wtsi/Nrbp1^tm3b(EUCOMM)Wtsi	C57BL/6N-Nrbp1^tm3b(EUCOMM)Wtsi/Wtsi	MGI:5767747
ht2	Nrbp1^tm3b(EUCOMM)Wtsi/Nrbp1^+	C57BL/6N-Nrbp1^tm3b(EUCOMM)Wtsi/Wtsi	MGI:5785083

Genotype
MGI:5767747

hm1

• Allelic Composition: Nrbp1^{tm3b(EUCOMM)Wtsi}/Nrbp1^{tm3b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nrbp1^{tm3b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0989_1_F09

Data Sources

IMPC Data for Nrbp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

abnormal trophoblast giant cell morphology ( J:261316 )

• abnormal trophoblast giant cell size and morphology at E9.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Genotype
MGI:5785083

ht2

• Allelic Composition: Nrbp1^{tm3b(EUCOMM)Wtsi}/Nrbp1⁺
• Genetic Background: C57BL/6N-Nrbp1^{tm3b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0989_1_F09

Data Sources

IMPC Data for Nrbp1

behavior/neurological

increased grip strength ( J:211773 )

IMPC - WTSI

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

immune system

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI