All Phenotypes Wrap53<tm1b(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wrap53^{tm1b(EUCOMM)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5637129

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wrap53^{tm1b(EUCOMM)Wtsi}/Wrap53^{tm1b(EUCOMM)Wtsi}	C57BL/6N-Wrap53^{tm1b(EUCOMM)Wtsi}/Wtsi	MGI:5767845
ht2	Wrap53^{tm1b(EUCOMM)Wtsi}/Wrap53⁺	C57BL/6N-Wrap53^{tm1b(EUCOMM)Wtsi}/Wtsi	MGI:5797917

Allelic Composition	Wrap53^{tm1b(EUCOMM)Wtsi}/Wrap53^{tm1b(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Wrap53^{tm1b(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0638_5_A03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wrap53^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Wrap53 mutation (34 available)

Data Sources

IMPC Data for Wrap53

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion

abnormal placenta morphology ( J:261316 )

• branching morphology defect

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - WTSI

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

Allelic Composition	Wrap53^{tm1b(EUCOMM)Wtsi}/Wrap53⁺
Genetic Background	C57BL/6N-Wrap53^{tm1b(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0638_5_A03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wrap53^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Wrap53 mutation (34 available)

Data Sources

IMPC Data for Wrap53

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:211773 )

IMPC - WTSI

growth/size/body

increased heart weight ( J:211773 )

IMPC - WTSI

increased lean body mass ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

IMPC - WTSI

decreased circulating cholesterol level ( J:211773 )

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - WTSI

decreased circulating LDL cholesterol level ( J:211773 )

IMPC - WTSI

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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