Phenotypes associated with this allele

• Allele Symbol: Wac^{tm2b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637134
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wac^tm2b(EUCOMM)Wtsi/Wac^tm2b(EUCOMM)Wtsi	C57BL/6N-Wac^tm2b(EUCOMM)Wtsi/Wtsi	MGI:6263866
ht2	Wac^tm2b(EUCOMM)Wtsi/Wac^+	C57BL/6N-Wac^tm2b(EUCOMM)Wtsi/Wtsi	MGI:6263865

Genotype
MGI:6263866

hm1

• Allelic Composition: Wac^{tm2b(EUCOMM)Wtsi}/Wac^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Wac^{tm2b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: MEPD0997_2_D04

Data Sources

IMPC Data for Wac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:6263865

ht2

• Allelic Composition: Wac^{tm2b(EUCOMM)Wtsi}/Wac⁺
• Genetic Background: C57BL/6N-Wac^{tm2b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: MEPD0997_2_D04

Data Sources

IMPC Data for Wac

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

hematopoietic system

decreased eosinophil cell number ( J:211773 )

♂

IMPC - WTSI

increased mean platelet volume ( J:211773 )

♂

IMPC - WTSI

increased monocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating triglyceride level ( J:211773 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

decreased circulating amylase level ( J:211773 )

♂

IMPC - WTSI

immune system

decreased eosinophil cell number ( J:211773 )

♂

IMPC - WTSI

increased monocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

♀

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

fusion of vertebral arches ( J:211773 )

♀

IMPC - WTSI