Phenotypes associated with this allele

• Allele Symbol: Shh^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637219
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shh^tm1b(EUCOMM)Wtsi/Shh^tm1b(EUCOMM)Wtsi	C57BL/6N-Shh^tm1b(EUCOMM)Wtsi/H	MGI:5757707
ht2	Shh^tm1b(EUCOMM)Wtsi/Shh^+	C57BL/6N-Shh^tm1b(EUCOMM)Wtsi/H	MGI:5757706

Genotype
MGI:5757707

hm1

• Allelic Composition: Shh^{tm1b(EUCOMM)Wtsi}/Shh^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Shh^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0339_3_A12

Data Sources

IMPC Data for Shh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5757706

ht2

• Allelic Composition: Shh^{tm1b(EUCOMM)Wtsi}/Shh⁺
• Genetic Background: C57BL/6N-Shh^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0339_3_A12

Data Sources

IMPC Data for Shh

adipose tissue

increased total body fat amount ( J:211773 )

♂

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - HAR

impaired glucose tolerance ( J:211773 )

♂

IMPC - HAR

skeleton

decreased bone mineral content ( J:211773 )

♂

IMPC - HAR